Search results for "Microvascular Network"
showing 3 items of 3 documents
Analysis of normal human retinal vascular network architecture using multifractal geometry
2017
AIM To apply the multifractal analysis method as a quantitative approach to a comprehensive description of the microvascular network architecture of the normal human retina. METHODS Fifty volunteers were enrolled in this study in the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and January 2014. A set of 100 segmented and skeletonised human retinal images, corresponding to normal states of the retina were studied. An automatic unsupervised method for retinal vessel segmentation was applied before multifractal analysis. The multifractal analysis of digital retinal images was made with computer algorithms, applying the standard box-counting method. Statistical analyse…
Hierarchical imaging and computational analysis of three-dimensional vascular network architecture in the entire postnatal and adult mouse brain
2021
The formation of new blood vessels and the establishment of vascular networks are crucial during brain development, in the adult healthy brain, as well as in various diseases of the central nervous system. Here, we describe a step-by-step protocol for our recently developed method that enables hierarchical imaging and computational analysis of vascular networks in postnatal and adult mouse brains. The different stages of the procedure include resin-based vascular corrosion casting, scanning electron microscopy, synchrotron radiation and desktop microcomputed tomography imaging, and computational network analysis. Combining these methods enables detailed visualization and quantification of t…
Potential Effects of Dietary Vitamin E in Laboratory Animal Diets on Results Obtained in Models of Disease
1998
This chapter will demonstrate the importance of vitamin E dietary supplements on cell functions, on different biomedical systems, and on diverse pathophysiological conditions, with special emphasis being placed on cardiovascular pathophysiology. These effects are presented as a rationale for the use of vitamin E supplements in diets of farm animals, pets, and also of laboratory animals. The latter point gives reason for considerable problems, which are discussed in the last chapter of this article.